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  • 山東海山藥業有限公司
    地址:德州市經濟開發區晶華北路
    聯系人:李經理
    電話:0534-2757988
    傳真:0534-2757986
    E-mail:sdhsyy@163.com
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    你的位置:首頁 >> 產品展示 >> 針劑  針劑
    單硝酸異山梨酯注射液
    來源:山東海山藥業有限公司官網 | 發布時間:2018-11-12 21:18:41 | 瀏覽次數:

     5ml*5支

    藥品名稱:

    通用名稱:單硝酸異山梨酯注射液
    英文名稱:Isosorbide Mononitrate Injection
    成分:
    本品主要是單硝酸異山梨酯。輔料為:丙二醇,磷酸氫二鈉,磷酸二輕鈉。
    適應癥:
    適用于心絞痛,與與洋地黃及(或)利尿劑合用治療慢性心力衰竭。
    用法用量:
    靜脈滴注。臨用前加0.9%氯化鈉注射液或5%葡萄糖注射液稀釋后靜脈滴注。藥物劑量可根據病人的反應調整,一般有效劑量為每日2~7mg。開始給藥速度為60μg/分,一般速度為60~120μg/分,每日一次,10天為一療程。
    禁忌:
    以下患者禁用本品: 
    --對硝基化合物過敏者 
    --急性心肌梗塞并低充盈壓 
    --左心功能不全并低充盈壓 
    --休克狀態 
    --嚴重低血壓(收縮壓低于90mmHg) 
    --心肌疾病并心內容積受限(肥厚梗阻型心臟病) 
    --縮窄性心包炎 
    --心包填塞 
    --合并使用西地那非(Slldenafil,商品名VIAGRA)。因西地那非可明顯增強單硝酸異山梨酯的降血壓作用。
    注意事項:
    1、給不明原因的肺循環高壓(原發性肺動脈高壓)的病人使用本品,由于對肺通氣不足部分血液供應相對增加的結果,可以導致動脈血氧含量的暫時降低(低氧血癥),這種情況特別見于心臟冠狀血管循環紊亂(冠心病)的病人。 
    2、因本品可增加高眼內壓,青光眼患者慎用. 
    3、在下列情況下需要特別小心的醫療監護: 
    --主動脈瓣狹窄和/或二尖瓣狹窄 
    --有循環調節紊亂傾向(體位性低血壓)的病人 
    --伴有顱內壓升高的疾病(到目前為止進一步壓力增加只見于靜脈輸入高劑量硝酸甘油后) 
    --嚴重腎功能損害的病人 
    --甲狀腺功能減退、營養不良及體重過低患者。
    不良反應:
    用藥初期常發生頭痛(所謂硝酸鹽性頭痛),通常可在繼續用藥幾天后消失。初次給藥或劑量增加時,常常會有血壓降低和/或體位性低血壓并伴有反射性脈率增加以及乏力、頭暈的感覺,有時會有惡心、嘔吐、瞬間皮膚發紅發熱和皮膚過敏反應。在少數情況下,可以出現嚴重的血壓降低并伴有心絞痛癥狀加重(硝酸鹽的矛盾效應)和/或顯著的矛盾性心動過緩。偶見報道有虛脫和昏厥(突然喪失知覺)。在個別情況下可發生剝脫性皮炎(炎癥性皮膚病)。有人描述過持續長期使用高劑量 5-單硝酸異山梨酯產生耐藥性和與其它硝基化合物的交叉耐藥性,應當避免持續高劑量使用,以防止效用的減弱或喪失。注意:服用本品后,因血流的相對重新分布進入換氣不足的肺小泡區域,會出現短暫性動脈血供氧不足。冠心病患者可因此導致心肌缺血。當出現任何上述未提到的不良反應時,應及時通知醫師、藥師。
    相互作用:
    同時應用降低血壓的藥物(抗高血壓藥)、β-阻斷劑、鈣拮抗劑、其它擴血管藥、安定藥或三環抗抑郁藥或酒精,可能增加本品的降血壓效應。同時應用一氧化二氮供體,如本品中的活性成分和西地那非(VIAGRA ),抗高血壓作用可明顯加強。本品可增強雙氫麥角胺的升血壓效應。同時服用非甾醇類抗風濕藥可能會使本品的效應降低。

     
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